Epitalon
Longevity & anti-agingAlso known as: Epithalon, Epithalone, AEDG peptide
A pineal tetrapeptide studied for telomere and aging effects, dosed in short yearly cycles.
2.What it is / mechanism
Epitalon is a tiny four amino acid peptide based on a substance from the pineal gland. In lab studies it switches on telomerase, the enzyme that maintains telomeres (the protective caps on the ends of chromosomes), and it appears to restore the pineal gland's melatonin rhythm. The idea is that supporting telomeres and circadian rhythm could slow some parts of aging. This is interesting in the lab but far from proven in people.s1
3.What the evidence supports
- Animal data onlyTurns on telomerase and lengthens telomeres in cells.s1
Shown in cell cultures and animal work, largely from one research group. Turning on telomerase also raises theoretical cancer questions.
- Animal data onlyExtends lifespan and lowers tumor rates in animals.s1
Mice lived about 12 to 13 percent longer in some studies. Not shown in humans.
- Anecdotal onlyImproves sleep, circadian rhythm, and aging markers in people.s2
Human evidence is limited and mostly from the original research group.
4.Dosing
| Route(s) | subcutaneous |
|---|---|
| Typical range | About 5 to 10 mg per day for 10 to 20 days, repeated only 2 to 3 times a year. |
| Frequency | Daily during a short cycle |
| Cycle guidance | Short, intensive cycles of 10 to 20 days, a few times a year. This is very different from peptides dosed daily for months. |
| Notes | The cycling pattern comes from the original Russian (Khavinson) protocols, the idea being short pulses rather than constant dosing. The blood is short, so it does not build up. |
5.Reconstitution
| Vial sizes | 10 mg, 50 mg |
|---|---|
| Diluent | Bacteriostatic water for multi dose vials, or sterile water for single use |
| Concentration | Example: a 50 mg vial plus 5 mL of water gives 10 mg/mL, so a 10 mg dose is 1 mL, which is 100 units on a U-100 syringe. Use more water for a smaller draw. |
| Notes | Epitalon usually ships as 10 mg to 100 mg freeze dried vials. |
Reconstitution calculator
Pick your vial size and how much water you add to see the draw volume and syringe units for a dose. Open the full calculator →
Inputs
Reminder: 1 mg = 1,000 mcg
Total amount stated on the vial, e.g. 5 mg.
How much diluent you draw into the vial.
Target dose per injection, in mcg. 1 mg = 1,000 mcg.
Result
Draw to
5 units
= 0.05 mL on your syringe
- Concentration
- 5,000 mcg/mL
- Per unit
- 50 mcg / unit
- Doses per vial
- 40
Educational estimate only. Not medical or dosing advice. Verify every calculation independently before use.
6.Storage & stability
Lyophilized (dry)
| Temp | Freeze for long term storage, or 2 to 8 short term |
|---|---|
| Shelf life | Many months when frozen |
| Notes | Keep dry and out of light until you mix it. |
Reconstituted
| Temp | 2 to 8 (refrigerated) |
|---|---|
| Shelf life | About 2 to 4 weeks |
| Notes | Do not freeze after mixing. Discard if cloudy or discolored. |
7.Reported side effects
- WarningUnknown long term risks, including a theoretical cancer concerns1Turning on telomerase is a theoretical cancer worry, though it has not been documented in the limited human use. Long term human safety has not been studied.
- CautionInjection site reactions(uncommon)s1
- InfoGenerally minimal reported effectss1
8.Interactions & stacking risks
- InfoOther longevity or peptide protocols
Often stacked with peptides like NAD+ or MOTS-c in longevity routines. There is little formal data on any combination.
9.Contraindications / who should avoid
- SeriousActive or recent cancer, or a strong family history
Its telomerase and cell growth effects are a theoretical concern where cancer is present.
- SeriousPregnancy or breastfeeding
No safety data in pregnancy or breastfeeding.
10.COA & purity notes
| Common adulterants | underdosed or mislabeled vials, material sold without clear content |
|---|---|
| Mislabeling | A recent third party COA helps confirm identity and purity. |
| Notes | Sold as unregulated research material. |
11.Sources
- [s1]PMC (in vitro and preclinical study) (2025). Epitalon increases telomere length in human cell lines through telomerase upregulation. in vitro link
- [s2]Longevity research review (2022). Epithalon (AEDG) peptide, pineal function, and aging (Khavinson research review). review
Last reviewed 2026-07-08 · status: reviewed