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Selank

Cognitive & nootropic

Also known as: Tuftsin analog, TP-7

A Russian anxiolytic nootropic peptide, used intranasally to ease anxiety without heavy sedation.

Safety:Used in Russia for anxiety but barely studied in Western trials. Usually a nasal spray, and generally mild, but the evidence base is small.

2.What it is / mechanism

Selank is a synthetic version of tuftsin, a small immune peptide, tweaked to last longer. It calms anxiety by modulating GABA and serotonin signaling and by raising BDNF, without the strong sedation or dependence of benzodiazepines. Users often notice a calming effect within a few days, much faster than an SSRI. It is used clinically in Russia for anxiety and is given as a nasal spray.s1

3.What the evidence supports

  • Limited human dataEases anxiety, often within a few days.s1

    From Russian clinical use and small studies, with little Western replication.

  • Animal data onlySupports focus and mood, and raises BDNF.s1

4.Dosing

Limited human data
Route(s)intranasal (most common), subcutaneous
Typical rangeIntranasal about 250 to 500 mcg per day, as a 0.15 percent solution.
FrequencyOnce or twice daily
Cycle guidanceShort courses, often 10 to 14 days, repeated as needed.
NotesUsually used as a nasal spray. The blood is short. As with Semax, for nasal use the concentration in mcg per drop matters, not syringe units.
s1

5.Reconstitution

Vial sizes5 mg, 10 mg
DiluentBacteriostatic or sterile water. Often mixed for nasal use rather than injection.
ConcentrationExample: a 5 mg vial plus 5 mL of water gives 1 mg/mL. For nasal use, work out mcg per drop. For subcutaneous use, a 300 mcg dose is 0.3 mL, which is 30 units on a U-100 syringe.
NotesSold as a lyophilized powder or as a ready made nasal spray.

Reconstitution calculator

Pick your vial size and how much water you add to see the draw volume and syringe units for a dose. Open the full calculator →

Inputs

Reminder: 1 mg = 1,000 mcg

mg

Total amount stated on the vial, e.g. 5 mg.

mL

How much diluent you draw into the vial.

mcg

Target dose per injection, in mcg. 1 mg = 1,000 mcg.

Result

Draw to

10 units

= 0.1 mL on your syringe

Concentration
2,500 mcg/mL
Per unit
25 mcg / unit
Doses per vial
20

Educational estimate only. Not medical or dosing advice. Verify every calculation independently before use.

General reconstitution technique →

6.Storage & stability

Lyophilized (dry)

TempFreeze for long term storage, or 2 to 8 short term
Shelf lifeMany months when frozen
NotesKeep dry and out of light until you mix it.

Reconstituted

Temp2 to 8 (refrigerated)
Shelf lifeAbout 2 to 4 weeks
NotesDo not freeze after mixing. Discard if cloudy or discolored.

General storage & stability guide →

7.Reported side effects

  • CautionNasal irritation(common)s1Mainly with the nasal spray.
  • CautionMild fatigue or drowsiness(uncommon)s1
  • CautionHeadache(uncommon)s1

8.Interactions & stacking risks

  • CautionSerotonergic medicines such as SSRIs

    It modulates serotonin, so use care alongside serotonergic drugs.

  • CautionSedatives or alcohol

    Could add to any calming or drowsy effect.

9.Contraindications / who should avoid

  • SeriousPregnancy or breastfeeding

    No safety data in pregnancy or breastfeeding.

10.COA & purity notes

Common adulterantsnasal sprays that vary in concentration, underdosed or mislabeled vials
MislabelingNasal products vary in strength, so check the concentration. A recent third party COA helps.
NotesUsed as a medicine in Russia, but not approved in the US. Gray market material is unregulated.

How to read a COA →

11.Sources

  1. [s1]Peptide research review (2023). Selank: anxiolytic and nootropic actions and Russian clinical use (review). review

Last reviewed 2026-07-08 · status: reviewed