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Sermorelin

Also known as Sermorelin acetate, GRF 1-29, Geref

Not approved in the USGrowth hormone

Last reviewed · Awaiting clinical review

Main safety concerns

It raises growth hormone, so it carries the usual GH cautions, including avoiding it with active cancer. It clears very fast, so it is dosed nightly.

Educational information, not medical advice. If you have symptoms that worry you, contact a clinician or emergency services.

What is known

A short acting growth hormone releasing hormone analog, once approved to treat and test for growth hormone deficiency.

Status:
Once FDA approved as Geref for growth hormone deficiency, but that product is no longer sold. Compounded and research material is not that product.[1]
Strongest evidence for any claim:

See the evidence claim by claim

On this page

What it is and how it works

Sermorelin is a shortened version of natural growth hormone releasing hormone, the first 29 amino acids that carry the activity. It signals the pituitary to release growth hormone in a natural pulse. Its is very short, only about 10 to 20 minutes, so its effect is brief and it is taken at night to match the body's own rhythm. It was once approved by the FDA, as Geref, to diagnose and treat growth hormone deficiency, mainly in children, and is now used off label and through .[1]

Evidence by claim

Each claim is graded on its own. Tap a grade to see what it does and does not mean.

Reported side effects

  • WarningHigher blood sugar[1]Growth hormone can raise blood sugar over time.
  • CautionFacial flushing(common)[1]Often right after the injection, and it passes quickly.
  • CautionDizziness or headache(common)[1]
  • CautionInjection site pain(common)[1]

Interactions and combination risks

  • InfoIpamorelin or CJC-1295

    Sometimes stacked with a GHRP like ipamorelin for a bigger growth hormone pulse.

  • CautionDiabetes medicines or insulin[1]

    Because growth hormone raises blood sugar, glucose control may need watching.

Who should avoid it

  • SeriousActive or recent cancer, or a strong family history

    Raising growth hormone and IGF-1 could in theory feed a tumor.

  • SeriousPregnancy or breastfeeding

    No safety data in pregnancy or breastfeeding.

Dosing

Placed after the evidence and risks on purpose. Nothing here is a recommendation for you.

Doses from small or early human studies
Route(s)subcutaneous
Typical rangeAbout 200 to 300 mcg at night, sometimes up to 500 mcg. Some protocols combine it with ipamorelin.
FrequencyOnce daily, before bed
Cycle guidanceOften run for several months, since the effect is gentle.
NotesThe very short , about 10 to 20 minutes, means it does not build up and must be taken regularly to matter. Take it on an empty stomach at night. Unlike ipamorelin, it can nudge up cortisol and prolactin a little.
[1]

For the equipment itself, see syringes, needles, and the rest of the kit.

Reconstitution

Vial sizes5 mg, 10 mg
DiluentBacteriostatic water for multi dose vials, or sterile water for single use
ConcentrationExample: a 5 mg vial plus 2.5 mL of water gives 2 mg/mL, so a 300 mcg dose is 0.15 mL, which is 15 units on a U-100 syringe.
NotesSermorelin usually ships as 5 mg or 10 mg freeze dried vials. Compounded sermorelin is also available by prescription in some places.

General reconstitution technique

Units and volume arithmetic

Converts between an amount and syringe units for the vial and diluent you enter. It starts empty and does not suggest an amount. Open the full calculator

Inputs

What do you want to convert?
  1. mg

    Total amount printed on the vial label.

    Sizes sold:
  2. mL

    Volume of bacteriostatic water already in the vial.

  3. Check the unit. 1 mg = 1,000 mcg, so the wrong one is a 1,000x error.

  4. U-100

    Printed on the syringe wrapper. Results over this size are shown as invalid.

Result

Fill in steps 1 to 3 to see the arithmetic. Nothing here is a suggested amount.

Settings live in the address bar, so a pasted link reopens this calculator as you left it.

Educational arithmetic only. It does not choose an amount for you and is not medical or dosing advice. Verify every calculation independently.

Storage and stability

Dry powder (lyophilized)

TemperatureFreeze for long term storage, or 2 to 8 short term
Shelf lifeMany months when frozen
NotesKeep dry and out of light until you mix it.

After mixing

Temperature2 to 8 (refrigerated)
Shelf lifeAbout 2 to 4 weeks
NotesDo not freeze after mixing. Discard if cloudy or discolored.

General storage and stability guide

COA and purity notes

Common adulterantsunderdosed or mislabeled vials, material sold without clear content
MislabelingA recent third party COA helps confirm identity and purity.
NotesSermorelin once had an approved version (Geref). Current research and compounded material is not that product.

How to read a COA

Sources

  1. [1]Sermorelin (Geref): approved use for growth hormone deficiency and drug overview

    U.S. FDA / Drugs.com 2024 (opens source in a new tab)· Regulatory record

  2. [2]Growth hormone secretagogues: history, mechanism of action, and clinical development

    JCSM Rapid Communications 2020 (opens source in a new tab)· Review

Last reviewed 8 July 2026 · editorial status: reviewed