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CJC-1295

Growth hormone

Also known as: CJC-1295 DAC, CJC-1295 no DAC, Mod GRF 1-29, Modified GRF (1-29)

A growth hormone releasing hormone analog that raises GH and IGF-1, sold in a long acting (DAC) and a short acting (no DAC) form.

Safety:It raises growth hormone and IGF-1, so it carries the same cautions as other GH boosters, including avoiding it with active cancer. The DAC and no DAC forms are dosed very differently, so know which one you have.

2.What it is / mechanism

CJC-1295 is a synthetic growth hormone releasing hormone (GHRH). It tells the pituitary to release the body's own growth hormone, which raises IGF-1. It comes in two forms. The DAC form (drug affinity complex) binds to albumin and lasts about a week, so a single shot holds GH and IGF-1 up for days. The no DAC form, also called Mod GRF 1-29, is the same core peptide without that anchor, so it clears in about 30 minutes and is dosed frequently to match natural GH pulses. The no DAC form is the one usually paired with ipamorelin.s1

3.What the evidence supports

  • Limited human dataRaises growth hormone and IGF-1, with the DAC form holding them up for days.s1

    Human pharmacokinetic studies show GH rising several fold and IGF-1 staying up for 9 to 11 days after a DAC dose.

  • Anecdotal onlyImproves body composition, recovery, and sleep.s2

    Popular claims, but not proven by outcome trials in healthy adults.

4.Dosing

Limited human data
Route(s)subcutaneous
Typical rangeDAC form: about 1 to 2 mg once or twice a week, used on its own. No DAC form (Mod GRF 1-29): about 100 mcg per dose, once or twice daily, often before bed and after training, usually paired with ipamorelin.
FrequencyWeekly for the DAC form. Daily, sometimes more, for the no DAC form.
Cycle guidanceOften run in cycles of several weeks to a few months.
NotesKnow which form you have, because the schedules are opposite. About 100 mcg of the no DAC form fully occupies the receptors, so more per dose adds little. The DAC form is usually used alone; adding a GHRP like ipamorelin on top can push growth hormone too high and worsen water retention.
s1

5.Reconstitution

Vial sizes2 mg, 5 mg
DiluentBacteriostatic water for multi dose vials, or sterile water for single use
ConcentrationExample: a 5 mg vial plus 2.5 mL of water gives 2 mg/mL, so 100 mcg of the no DAC form is 0.05 mL, which is 5 units on a U-100 syringe. A 1 mg dose of the DAC form is 0.5 mL, or 50 units.
NotesSold as 2 mg or 5 mg freeze dried vials. The label should say whether it is the DAC or no DAC form.

Reconstitution calculator

Pick your vial size and how much water you add to see the draw volume and syringe units for a dose. Open the full calculator →

Inputs

Reminder: 1 mg = 1,000 mcg

mg

Total amount stated on the vial, e.g. 5 mg.

mL

How much diluent you draw into the vial.

mcg

Target dose per injection, in mcg. 1 mg = 1,000 mcg.

Result

Draw to

25 units

= 0.25 mL on your syringe

Concentration
1,000 mcg/mL
Per unit
10 mcg / unit
Doses per vial
8

Educational estimate only. Not medical or dosing advice. Verify every calculation independently before use.

General reconstitution technique →

6.Storage & stability

Lyophilized (dry)

TempFreeze for long term storage, or 2 to 8 short term
Shelf lifeMany months when frozen
NotesKeep dry and out of light until you mix it.

Reconstituted

Temp2 to 8 (refrigerated)
Shelf lifeAbout 2 to 4 weeks
NotesDo not freeze after mixing. Discard if cloudy or discolored.

General storage & stability guide →

7.Reported side effects

  • WarningHigher blood sugars1Growth hormone can raise blood sugar and lower insulin sensitivity over time.
  • CautionInjection site reactions(common)s1
  • CautionFacial flushing or headache(common)s1
  • CautionWater retention and puffiness(common)s1More common with the long acting DAC form, from the sustained growth hormone.
  • CautionTingling or numbness in the hands(uncommon)s1A growth hormone effect, more likely with the DAC form.

8.Interactions & stacking risks

  • InfoIpamorelin

    The no DAC form is commonly paired with ipamorelin for a bigger, synergistic GH pulse. The DAC form is usually used on its own.

  • CautionDiabetes medicines or insulins1

    Because growth hormone raises blood sugar, glucose control may need watching.

9.Contraindications / who should avoid

  • SeriousActive or recent cancer, or a strong family history

    Raising growth hormone and IGF-1 could in theory feed a tumor.

  • SeriousPregnancy or breastfeeding

    No safety data in pregnancy or breastfeeding.

10.COA & purity notes

Common adulterantsthe DAC and no DAC forms mislabeled or swapped, underdosed or mislabeled vials
MislabelingThe most common problem is not knowing which form you have, since they are dosed completely differently. The label and COA should clearly say DAC or no DAC.
NotesSold as unregulated research material.

How to read a COA →

11.Sources

  1. [s1]Journal of Clinical Endocrinology & Metabolism (2006). Prolonged stimulation of growth hormone and IGF-1 by CJC-1295, a long-acting GHRH analog. rct
  2. [s2]JCSM Rapid Communications (2020). Growth hormone secretagogues: history, mechanism of action, and clinical development. review link

Last reviewed 2026-07-08 · status: reviewed