Ipamorelin
Growth hormoneAlso known as: Ipamorelin acetate
A selective growth hormone releaser that gives a clean GH pulse without raising cortisol or prolactin.
2.What it is / mechanism
Ipamorelin mimics ghrelin, the hunger hormone, at the growth hormone secretagogue receptor (GHSR). This triggers the pituitary to release a pulse of growth hormone. What sets it apart is selectivity: unlike some older releasers, it does not meaningfully raise cortisol, prolactin, or ACTH, so it gives a cleaner pulse without the stress hormone baggage. It works through a different receptor than GHRH peptides, which is why it pairs well with CJC-1295.s1
3.What the evidence supports
- Limited human dataTriggers a clean growth hormone pulse without raising cortisol or prolactin.s1
Shown in animal and early human work. It is considered the most selective of the growth hormone releasers.
- Anecdotal onlyImproves body composition, recovery, and sleep.s2
Popular claims, not proven by outcome trials in healthy adults.
4.Dosing
| Route(s) | subcutaneous |
|---|---|
| Typical range | About 100 to 300 mcg per dose, one to three times a day. A common pattern is 200 to 300 mcg before bed, often with 100 mcg of CJC-1295 (no DAC). |
| Frequency | Once to three times daily |
| Cycle guidance | Often run in cycles of several weeks to a few months. |
| Notes | The blood is about 2 hours, so it does not build up. Dose on an empty stomach, since food, especially carbs and fat, blunts the growth hormone pulse. Timing it before bed lines up with the body's own release. |
5.Reconstitution
| Vial sizes | 5 mg, 10 mg |
|---|---|
| Diluent | Bacteriostatic water for multi dose vials, or sterile water for single use |
| Concentration | Example: a 5 mg vial plus 2.5 mL of water gives 2 mg/mL, so a 300 mcg dose is 0.15 mL, which is 15 units on a U-100 syringe. |
| Notes | Ipamorelin usually ships as 5 mg or 10 mg freeze dried vials. |
Reconstitution calculator
Pick your vial size and how much water you add to see the draw volume and syringe units for a dose. Open the full calculator →
Inputs
Reminder: 1 mg = 1,000 mcg
Total amount stated on the vial, e.g. 5 mg.
How much diluent you draw into the vial.
Target dose per injection, in mcg. 1 mg = 1,000 mcg.
Result
Draw to
10 units
= 0.1 mL on your syringe
- Concentration
- 2,500 mcg/mL
- Per unit
- 25 mcg / unit
- Doses per vial
- 20
Educational estimate only. Not medical or dosing advice. Verify every calculation independently before use.
6.Storage & stability
Lyophilized (dry)
| Temp | Freeze for long term storage, or 2 to 8 short term |
|---|---|
| Shelf life | Many months when frozen |
| Notes | Keep dry and out of light until you mix it. |
Reconstituted
| Temp | 2 to 8 (refrigerated) |
|---|---|
| Shelf life | About 2 to 4 weeks |
| Notes | Do not freeze after mixing. Discard if cloudy or discolored. |
7.Reported side effects
8.Interactions & stacking risks
- InfoCJC-1295
Commonly paired with CJC-1295 (no DAC) for a larger, synergistic GH pulse, since the two work through different receptors.
Because growth hormone raises blood sugar, glucose control may need watching.
9.Contraindications / who should avoid
- SeriousActive or recent cancer, or a strong family history
Raising growth hormone and IGF-1 could in theory feed a tumor.
- SeriousPregnancy or breastfeeding
No safety data in pregnancy or breastfeeding.
10.COA & purity notes
| Common adulterants | underdosed or mislabeled vials, material sold without clear content |
|---|---|
| Mislabeling | As with any research peptide, a recent third party COA helps confirm identity and purity. |
| Notes | Sold as unregulated research material. |
11.Sources
- [s1]European Journal of Endocrinology (1998). Ipamorelin, the first selective growth hormone secretagogue. preclinical animal
- [s2]JCSM Rapid Communications (2020). Growth hormone secretagogues: history, mechanism of action, and clinical development. review link
Last reviewed 2026-07-08 · status: reviewed