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KPV

Anti-inflammatory & immune

Also known as: Lysine-Proline-Valine, alpha-MSH (11-13) fragment

A small anti inflammatory tripeptide from the tail of alpha-MSH, studied most for gut inflammation.

Safety:Human evidence is limited and mostly from animal gut studies. Its safety record looks clean so far, but it has not been tested in long human trials.

2.What it is / mechanism

KPV is the last three amino acids of alpha-MSH, a natural hormone. Researchers found that this short tail keeps most of the anti inflammatory effect of the full hormone without the pigment or strong hormone signaling. It appears to calm inflammation from inside the cell, and it is taken up efficiently through a gut transporter called PepT1. It is the anti inflammatory part of the KLOW blend.s1

3.What the evidence supports

  • Animal data onlyReduces gut inflammation and related markers.s1

    The strongest area, with animal studies showing inflammatory markers cut roughly in half. No completed human dose finding trial.

  • Animal data onlyCalms inflammation in skin and elsewhere.s1

    Supported by cell and animal work, with human use running ahead of the evidence.

  • Anecdotal onlyUsed for gut issues, skin flares, and general inflammation.

4.Dosing

Anecdotal only
Route(s)subcutaneous, oral (it is absorbed intact through a gut transporter)
Typical rangeInjectable: about 200 to 500 mcg per day, sometimes up to 1,000 mcg. Oral capsules are also used, often around 10 to 20 mg per day for gut targeted effects.
FrequencyOnce or twice daily
Cycle guidanceOften run for a few weeks.
NotesNo human dose finding trial sets an official dose. The blood is short, around 2 hours, so it does not build up. Oral KPV is used specifically for gut inflammation because it is absorbed intact.
s1

5.Reconstitution

Vial sizes5 mg, 10 mg
DiluentBacteriostatic water for multi dose vials, or sterile water for single use
ConcentrationExample: a 5 mg vial plus 1 mL of water gives 5 mg/mL, so a 500 mcg dose is 0.1 mL, which is 10 units on a U-100 syringe.
NotesKPV usually ships as 5 mg or 10 mg freeze dried vials. Oral capsule forms also exist for gut use.

Reconstitution calculator

Pick your vial size and how much water you add to see the draw volume and syringe units for a dose. Open the full calculator →

Inputs

Reminder: 1 mg = 1,000 mcg

mg

Total amount stated on the vial, e.g. 5 mg.

mL

How much diluent you draw into the vial.

mcg

Target dose per injection, in mcg. 1 mg = 1,000 mcg.

Result

Draw to

10 units

= 0.1 mL on your syringe

Concentration
2,500 mcg/mL
Per unit
25 mcg / unit
Doses per vial
20

Educational estimate only. Not medical or dosing advice. Verify every calculation independently before use.

General reconstitution technique →

6.Storage & stability

Lyophilized (dry)

TempFreeze for long term storage, or 2 to 8 short term
Shelf lifeMany months when frozen
NotesKeep dry and out of light until you mix it.

Reconstituted

Temp2 to 8 (refrigerated)
Shelf lifeAbout 2 to 4 weeks
NotesDo not freeze after mixing. Discard if cloudy or discolored.

General storage & stability guide →

7.Reported side effects

  • WarningUnknown long term risks, since there is no long term human safety data
  • CautionInjection site irritation(uncommon)s1
  • InfoGenerally very well tolerated, with no skin darkenings1Unlike its parent hormone alpha-MSH, KPV does not darken skin at usual doses.

8.Interactions & stacking risks

  • InfoKLOW blend

    KPV is the anti inflammatory part of the KLOW blend, combined there with BPC-157, TB-500, and GHK-Cu.

9.Contraindications / who should avoid

  • SeriousPregnancy or breastfeeding

    No safety data in pregnancy or breastfeeding.

10.COA & purity notes

Common adulterantsunderdosed or mislabeled vials, material sold without clear content
MislabelingAs with any research peptide, a recent third party COA helps confirm identity and purity.
NotesSold as unregulated research material, both as an injectable and as oral capsules.

How to read a COA →

11.Sources

  1. [s1]PMC (preclinical study) (2019). KPV ameliorates LPS-induced intestinal inflammation and mucosal barrier damage. preclinical animal link
  2. [s2]Peptide research review (2023). KPV and the anti-inflammatory activity of the alpha-MSH C-terminus (review). review

Last reviewed 2026-07-08 · status: reviewed