BPC-157
Also known as Body Protection Compound 157, Bepecin, PL 14736, Pentadecapeptide BPC 157
Last reviewed · Awaiting clinical review
Main safety concerns
Human evidence is thin, with no completed randomized trials. Because it encourages new blood vessel growth, it is usually avoided by anyone with active or recent cancer.
- SeriousAvoid if: Active or recent cancer, or a strong family history
- SeriousAvoid if: Pregnancy or breastfeeding
- WarningUnknown long term risks, since there is no long term human safety data
Educational information, not medical advice. If you have symptoms that worry you, contact a clinician or emergency services.
What is known
A synthetic peptide of 15 amino acids, studied mostly in animals for healing tendon, ligament, muscle, and gut tissue.
- Strongest evidence for any claim:
On this page
What it is and how it works
BPC-157 is a synthetic peptide made of 15 amino acids, based on a protective protein found in human gastric juice. In animal studies it appears to speed up tissue repair by encouraging new blood vessel growth (), boosting growth factor and signaling, and acting on the nitric oxide system, with broad protective effects on cells. One striking thing about it is the mismatch between how fast it clears and how long it works. The peptide leaves the bloodstream within about 15 to 30 minutes, yet its tissue effects can last for weeks. That suggests the benefit is driven at the tissue level rather than by holding a steady level in the blood.[1] [2]
Evidence by claim
Each claim is graded on its own. Tap a grade to see what it does and does not mean.
Speeds healing of tendon, ligament, muscle, and bone injuries.
Source type: Animal study, Review
Consistent across many rodent studies. Not yet shown in controlled human trials.
Protects and heals gut tissue, such as ulcers and colitis.
Source type: Review
A large body of rodent work from the original research group. Independent human confirmation is missing.
Small uncontrolled human reports describe benefit, for example in interstitial cystitis and knee pain.
Source type: Review
Fewer than about 30 people in total across published human reports, with no placebo groups or randomized trials.
Broad body wide benefits are often claimed, such as neuroprotection or better mood.
Source type: Review
Based on animal mechanisms and community reports, not human outcome data.
Reported side effects
- WarningUnknown long term risks, since there is no long term human safety data[2] [3]Rodent studies report little toxicity, but no long term human safety trials have been completed.
- CautionInjection site soreness, redness, or bruising(common)[2]The most commonly reported effect. Usually mild and local.
- CautionHeadache or light headedness(uncommon)[2]
- CautionNausea or digestive upset(uncommon)[2]
- InfoFatigue(uncommon)[2]
Interactions and combination risks
Often stacked in community protocols for recovery. No human data supports the combination.
BPC-157 promotes new blood vessel growth, which could in theory feed a tumor. Avoid it alongside an active or recent cancer.
Who should avoid it
- SeriousActive or recent cancer, or a strong family history
New blood vessel growth (angiogenesis) could in theory feed an existing or hidden tumor. This is a concern based on mechanism and animal data, not a proven human outcome, but clinicians generally advise avoiding it.
- SeriousPregnancy or breastfeeding
No safety data in pregnancy or breastfeeding.
Dosing
Placed after the evidence and risks on purpose. Nothing here is a recommendation for you.
| Route(s) | subcutaneous, often near the injury site, intramuscular, oral (stable in the stomach, though how much reaches the body is unclear) |
|---|---|
| Typical range | 200 to 500 mcg per day, most often around 250 to 500 mcg. Community protocols run up to about 1,000 mcg per day. |
| Frequency | Once or twice daily |
| Half life used in the model | 30 minutes |
| Cycle guidance | About 4 to 8 weeks for an acute injury, or 8 to 12 weeks for chronic problems. |
| Notes | No human dose finding studies exist, so these ranges come from animal scaling and community practice. Because it clears the blood so quickly, with a under 30 minutes in rat and dog studies, BPC-157 does not build up in the blood. Daily or twice daily dosing is about keeping steady exposure at the tissue, not reaching a blood plateau. Many people inject close to the target area. |
For the equipment itself, see syringes, needles, and the rest of the kit.
Reconstitution
| Vial sizes | 5 mg, 10 mg |
|---|---|
| Diluent | Bacteriostatic water (0.9% benzyl alcohol) for multi dose vials, or sterile water for single use |
| Concentration | Example: a 5 mg vial plus 2 mL of water gives 2.5 mg/mL, which is 25 mcg per unit on a U-100 syringe. A 10 mg vial plus 2 mL gives 5 mg/mL. Adjust the water volume to land on an easy unit count. |
| Notes | BPC-157 usually ships as 5 mg or 10 mg freeze dried vials. |
General reconstitution technique
Units and volume arithmetic
Converts between an amount and syringe units for the vial and diluent you enter. It starts empty and does not suggest an amount. Open the full calculator
Result
Fill in steps 1 to 3 to see the arithmetic. Nothing here is a suggested amount.
Settings live in the address bar, so a pasted link reopens this calculator as you left it.
Educational arithmetic only. It does not choose an amount for you and is not medical or dosing advice. Verify every calculation independently.
Storage and stability
Dry powder (lyophilized)
| Temperature | Freeze for long term storage, or 2 to 8 short term |
|---|---|
| Shelf life | Many months to about 2 years when frozen |
| Notes | Keep dry and out of light until you mix it. |
After mixing
| Temperature | 2 to 8 (refrigerated) |
|---|---|
| Shelf life | About 2 to 4 weeks |
| Notes | Do not freeze after mixing. Discard if cloudy or discolored. |
COA and purity notes
| Common adulterants | underdosed or mislabeled material, where the real content is below the label, BPC-157 and TB-500 blends sold as pure BPC-157, bacterial endotoxin or contaminants from non sterile production |
|---|---|
| Mislabeling | Research suggests many reported BPC-157 side effects actually trace back to impurities, wrong dosing, or hidden blends rather than the peptide itself, which is why a third party COA is worth checking. |
| Notes | Sold as a research chemical. It is not an FDA approved drug and has no USP monograph, so manufacturing quality is unregulated and varies. |
Sources
[1]Pharmacokinetics, distribution, metabolism, and excretion of body protective compound 157, a potential drug for treating various wounds, in rats and dogs
Frontiers in Pharmacology 2022 (opens source in a new tab)· Animal study[2]Multifunctionality and Possible Medical Application of the BPC 157 Peptide, Literature and Patent Review
Pharmaceuticals (MDPI) 2025 (opens source in a new tab)· Review[3]BPC-157 benefits, dosage, and side effects (evidence overview)
Examine.com 2025 (opens source in a new tab)· Review[4]Pharmacy Compounding Advisory Committee, 503A bulk drug substances review (includes BPC-157)
U.S. Food & Drug Administration 2026 (opens source in a new tab)· Regulatory record[5]FDA Briefing Document, Pharmacy Compounding Advisory Committee, July 23 to 24, 2026: BPC-157 Related Bulk Drug Substances
U.S. Food & Drug Administration 2026 (opens source in a new tab)· Regulatory record[6]World Anti-Doping Code International Standard: Prohibited List 2026
World Anti-Doping Agency (WADA) 2026 (opens source in a new tab)· Regulatory record
Last reviewed 7 July 2026 · editorial status: reviewed